Hyaluronic Acid in Modern Dentistry: Evidence-Based Applications and Clinical Protocols

— Biological and cellular basis of periodontal wound healing
— Role of soft tissues, epithelium, and gingival connective tissue in healing
— Importance of rapid soft tissue healing for deep tissue regeneration
— Gain of attachment as the primary clinical objective
— Complexity and specialization of the periodontal soft tissue compartment
— Insights from wound healing studies across medicine
— Cellular and molecular mechanisms underlying periodontal regeneration
— Historical perspective on hyaluronic acid (HA) since 1934
— Role of HA in the periodontal ligament and soft tissue healing
— Application of HA in mucogingival and regenerative periodontal surgery
— Evidence from three decades of research supporting HA use
— Integration of HA into validated surgical protocols
— Clinical outcomes and benefits of HA in periodontal regeneration.

— Role of hyaluronic acid in enhancing non-surgical periodontal therapy
— Biological properties of hyaluronic acid relevant to periodontal healing
— Applications of hyaluronic acid in periodontology
— Review of current studies and scientific evidence
— Clinical uses of hyaluronic acid in minimal invasive non-surgical therapy
— Impact of hyaluronic acid on treatment outcomes
— Integration of hyaluronic acid with minimal invasive therapy principles
— Potential shift in indications between non-surgical and surgical therapy
— Future perspectives for hyaluronic acid in periodontal care
— Conclusion and clinical takeaways.

— Definition and principles of minimal invasive therapy
— Relevance of minimal invasive approaches in chronic periodontitis
— Goals of minimal invasive therapy in periodontal treatment
— Reducing patient discomfort and protecting hard and soft tissues
— Enhancing healing outcomes through minimal intervention
— Personalised periodontal therapy and avoidance of overtreatment
— Selecting appropriate instruments for minimal invasive procedures
— Treatment steps within a minimal invasive workflow
— Application of minimal invasive therapy across all phases of periodontal treatment
— Evidence and support for minimal invasive therapy in the literature.

— Importance of recognizing and treating periodontitis in everyday practice
— Integration of new periodontal classifications and treatment guidelines
— Developing a solid perio concept for clinical practice
— Overview of new treatment methods in periodontology
— Role and effectiveness of biologics in perio and implant therapy
— Differences between types of hyaluronic acid
— Application of biologics in both periodontology and implantology
— Creating a modern, practice-oriented perio and implant workflow
— Ensuring predictability and success in implant therapy for perio patients
— Preservation of bone and soft tissue for functional and aesthetic outcomes.

— Importance of bone reconstruction and modification for implant placement
— Basic principles of bone augmentation
— Overview of bone augmentation techniques: shell techniques, bone blocks, titanium grids, umbrella technique
— Significance of graft stability for primary and long-term implant success
— Role and effects of hyaluronic acid in regenerative treatments
— Use of cross-linked hyaluronic acid (xHyA) for adjunctive therapy
— Practical application of sticky bone in bone augmentation
— Advantages of sticky bone in clinical practice
— Developing a modern, practice-oriented augmentation workflow
— Integration of regenerative techniques into daily practice
— Evidence and clinical outcomes supporting biologics in implantology.

— Role of non-surgical therapy in periodontitis treatment sequence
— Importance of oral hygiene and risk factor control
— Limitations of non-surgical therapy and need for additional treatment
— Introduction to hyaluronic acid in periodontal therapy
— Scientific background of hyaluronic acid
— Timing and indications for using hyaluronic acid in non-surgical treatment
— Impact of hyaluronic acid on non-surgical treatment outcomes
— Timing and indications for using hyaluronic acid in surgical treatment
— Impact of hyaluronic acid on surgical treatment outcomes
— Evidence and results from clinical applications
— Practical integration of hyaluronic acid in periodontal therapy.

— Historical background and development of hyaluronic acid research
— Biologic properties of hyaluronic acid and its role in wound healing
— Cross-linking technology and extended biologic activity
— Pre-clinical evidence supporting hyaluronic acid in dentistry
— Clinical applications in non-surgical periodontal therapy
— Hyaluronic acid in the surgical treatment of periodontitis
— Use of hyaluronic acid in mucogingival surgery
— Hyaluronic acid in bone regeneration and lateral bone augmentation
— Application of hyaluronic acid in socket preservation
— Role of hyaluronic acid in managing peri-mucositis and peri-implantitis.

— Importance of thorough subgingival debridement in periodontal therapy
— Limitations of complete plaque and calculus removal
— Impact of anatomical, operator-related, and patient-related factors
— Evidence on residual plaque after instrumentation
— Need for adjunctive antimicrobial materials in periodontal therapy
— Introduction to the clean and seal concept
— Role of sodium hypochlorite/amino acid gels in biofilm elimination
— Role of cross-linked hyaluronic acid (xHyA) in periodontal regeneration
— Pre-clinical and clinical data supporting the clean and seal approach
— Clinical benefits in periodontal and peri-implant infections
— Reduction of pathogenic bacteria and improved histologic outcomes
— Potential to reduce the need for periodontal surgery
— Clean and seal in step-2 periodontitis treatment
— Clean and seal in step-3 periodontitis treatment
— Clean and seal in managing peri-mucositis and peri-implantitis.